Endocrine Abstracts

Background: Electronic endocrinology advice and Guidance (e-Endo A&G) via NHS e-Referral Service was introduced at University Hospitals of Leicester NHS Trust (UHL) in March 2017 to address General Practitioners’ (GP) non-urgent endocrinology clinical concerns. Primary aims of the service, was to prevent inappropriate outpatient visits, avoid acute admissions and reducing length of time in resolution of queries.Objectives: To retrospectively eva...

Introduction: Daytime support from the diabetes-team reduces pressure on acute services however out-of-hours less support exists and diabetes related attendances to A&E are a potentially avoidable burden on resources. With the introduction of paediatric diabetes best-practice-tariff, recommendations included 24 h access to trained diabetes professionals for patients with known diabetes. In 2013 our three institutions created a consultant led out-of-hours paediatric diabete...

Introduction: The ESPE e-Learning web portal is a free, globally accessible online tool to enhance learning in Paediatric Endocrinology and Diabetes. Since August 2022, the e-learning content includes 30 accredited hours of ESPE/ISPAD e-learning Continuing Medical Education (CME) courses with ten core modules each in Paediatric Endocrinology, Paediatric Endocrinology in Resource Limited Setting (RLS) and Paediatric Diabetes. The CME modules were created by wor...

Introduction and aim: An e-mail based GP advisory service was launched by the authors’ centre in 2005. The PCT commissioned the service in July 2009. Enquiries are handled by specialist registrars with consultant supervision. The charge is £23/enquiry.Pre-commissioning, annual audits demonstrated an efficient and popular service, enhancing communication links between primary and secondary/tertiary care.We re-audited the s...

Introduction: RAMPs (receptor activity-modifying proteins) are single-pass transmembrane accessory proteins required for appropriate signalling of the G-protein coupled receptors; CRLR (Calcitonin receptor like receptor) and CTR (Calcitonin receptor). There are three forms of human RAMPs known as, RAMP1, 2 and 3. RAMP3 heterodimerises with CRLR or CTR to form a high affinity receptor for the peptide hormones adrenomedullin and amylin, respectively. However, the exact mechanism...

Recently there has been reports that the administration of hormonal contraceptives alter the metabolic processes and micronutrients levels. Meanwhile some of these micronutrients are cofactors and or coenzymes of enzymes and are involved in important metabolic pathways. We compared the influence of three contraceptive methods (oral contraceptive, injectables and implants) on serum levels of Iron, ferritin, copper, ceruloplasmin and Vitamin E, using standard methods. Blood samp...

Background: Confident recognition of atypical genitalia of the newborn and early referral to specialist centres allows for the smooth and successful management of DSD patients. Midwives conduct the majority of newborn infant physical exam (NIPE) yet may not be confident in recognising DSD and talking to families affected.Aim: To develop an e-learning module for examining newborn genitalia, recognising the significance of differences in genital appearance...

As for many tumor types, it has been shown that the Akt pathway is overexpressed and activated in human pituitary tumors. Thus, pituitary tumors may be sensitive to the anti-proliferative effects of mTOR inhibitors. However, part of non-functioning pituitary tumors are rapamycin-resistant. Torin1, second-generation ATP-competitive mTOR kinase inhibitor, suppresses both mTORC1 and mTORC2 complexes. To evaluate the in vitro effects of the mTOR inhibitor Torin1 on pituitar...

Background: Obesity represents a cardiovascular risk factor. Monocyte chemoattractant protein-1 (MCP-1) is a known regulator of monocyte recruitment to sites of inflammation, and participates at the early phases of atherogenesis. Apolipoproteins, as part of the lipoprotein particles, are classically coupled with cardiovascular risk distinction.Aims: To assess the association of anthropometric parameters, insulin resistance and MCP-1 levels with classic l...

Objective: To investigate the influence of vitamin E (VE) and selenium (Se) on apoptosis of human thyrocyte induced by H2O2.Methods: The human thyroid epithelium cells (TEC) from normal para-adenoma tissues of patients with thyroid adenoma resection were cultured. In prevention groups, vitamin E (50 μmol/l), selenium (10–7 mol/l) or serum-free medium was respectively added into thyrocytes of monolayer culture before H...